283 Research paper – Cheng – 2014 – Antibiotic alternatives_ the substitution of antibiotics in animal husbandry

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283 Research paper – Cheng – 2014 – Antibiotic alternatives_ the substitution of antibiotics in animal husbandry

In Significant Impact Groups:
Specific alternatives \ New antibiotics
Species targeted: Pigs;Poultry;Dairy;Beef;Sheep;Other;
Age: Young;Adult;
Summary:
Where to find the original material:
Country: CN
It is a common practice for decades to use of sub-therapeutic dose of antibiotics in food-animal feeds to prevent animals from diseases and to improve production performance in modern animal husbandry. Concerns over the increasing emergence of antibiotic-resistant bacteria have prompted efforts to develop so-called alternatives to antibiotics. This review summarizes recent development and perspectives of alternatives to antibiotics. The mechanism of actions, applications of the alternatives such as immunity modulating agents, bacteriophages and their lysins, antimicrobial peptides, pro-, pre-, and synbiotics, plant extracts, inhibitors targeting pathogenicity, and feeding enzymes are discussed. Lastly, the feasibility of these alternatives is analyzed. The conclusion is that these alternatives are not likely to replace antibiotics in animals in a foreseeable future. Therefore, prudent use of antibiotics and the establishment of scientific monitoring systems are the best and fastest way to limit the adverse effects of overuse of antibiotics.