294 Research paper – Tang – 2016 – Oral administration of synthetic porcine beta-defensin-2 improves growth performance and cecal microbial flora and down-regulates the expression of intesti

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294 Research paper – Tang – 2016 – Oral administration of synthetic porcine beta-defensin-2 improves growth performance and cecal microbial flora and down-regulates the expression of intesti

In Significant Impact Groups:
Feed / gut health \ Feed additives and supplements Specific alternatives
Species targeted: Pigs;
Age: Young;
Summary:
Where to find the original material:
Country: CN
Synthetic porcine beta-defensin-2 (pBD-2) was tested as an alternative to antimicrobial growth-promoters in pig production. Thirty 21-day weaned piglets were challenged with Escherichia coli, and orally dosed with either sterile water (CON), pBD-2 (BD) or neomycin sulphate (NS) twice daily for 21 days. Therefore, pBD-2 has antimicrobial activity in piglets, and it can improve growth performance, reduce inflammatory cytokine expression and affect intestinal morphological indices in the same way as probiotics. Moreover, pBD-2 has a more positive effect on intestinal morphological indices and intestinal probiotics of piglets than does NS. Therefore, the present results suggest that pBD-2 may be a suitable replacement for NS in piglets.