294 – Oral administration of synthetic porcine beta-defensin-2 improves growth performance and cecal microbial flora and down-regulates the expression of intestinal toll-like receptor-4 and inflammatory cytokines in weaned piglets challenged with enterotoxigenic Escherichia coli (Research paper – Tang – 2016)Click here for resource
In Significant Impact Groups: Feed / gut health \ Feed additives and supplements; Specific alternatives
Species targeted: Pigs;
Synthetic porcine beta-defensin-2 (pBD-2) was tested as an alternative to antimicrobial growth-promoters in pig production. Thirty 21-day weaned piglets were challenged with Escherichia coli, and orally dosed with either sterile water (CON), pBD-2 (BD) or neomycin sulphate (NS) twice daily for 21 days. Therefore, pBD-2 has antimicrobial activity in piglets, and it can improve growth performance, reduce inflammatory cytokine expression and affect intestinal morphological indices in the same way as probiotics. Moreover, pBD-2 has a more positive effect on intestinal morphological indices and intestinal probiotics of piglets than does NS. Therefore, the present results suggest that pBD-2 may be a suitable replacement for NS in piglets.
Where to find the original material: https://onlinelibrary.wiley.com/doi/full/10.1111/asj.12540; https://doi.org/10.1111/asj.12540