370 Research paper – Du – 2020 – Antimicrobial Effect of Zophobas morio Hemolymph against Bovine Mastitis Pathogens

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370 Research paper – Du – 2020 – Antimicrobial Effect of Zophobas morio Hemolymph against Bovine Mastitis Pathogens

In Significant Impact Groups:
Specific alternatives \
Species targeted: Dairy;
Age: Adult;
Summary:
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Country: CN
In the present study, we showed the protective effect of Zophobas morio (Z. morio) hemolymph on bovine mammary epithelial cells against bacterial infection. Z. morio hemolymph directly kills both Gram-positive and Gram-negative bacteria through membrane permeation and prevents the adhesion of E. coli or the clinically isolated S. simulans strain to bovine mammary epithelial (MAC-T) cells. In addition, Z. morio hemolymph downregulates the expression of nucleotide-binding oligomerization domain (NOD)-like receptor family member pyrin domain-containing protein 3 (NLRP3), caspase-1, and NLRP6, as well as inhibits the secretion of interleukin-1 beta (IL-1 beta) and IL-18, which attenuates E. coli or S. simulans-induced pyroptosis. Overall, our results suggest the potential role of Z. morio hemolymph as a novel therapeutic candidate for bovine mastitis.