Research paper Modelling concentrations of antimicrobial drugs: comparative pharmacokinetics of cephalosporin antimicrobials and accuracy of allometric scaling in food-producing and companion animals

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Significant Impact Group(s): Other
Species targeted: Poultry;Dairy;Beef;
Age: Young;Adult;
Outcome Parameter(s): Pharmacokinetic parameters of antibiotics (clearance, volume of distribution, half-life)
Summary: Distribution of cephalosporin antimicrobials in animals bodies is in general very similar between animal species. It was shown that generalizing of amounts of antimicrobial values for volume of distribution and clearance of most cephalosporins across food-producing and companion animal species can be performed using allometric scaling.
73 Research paper – Averne – 2016 – Modelling concentrations of antimicrobial drugs_ comparative pharmacokinetics of cephalosporin antimicrobials and accuracy of allometric scalin
Where to find the original material:
https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-016-0817-2; https://doi.org/10.1186/s12917-016-0817-2
Country: NL

73 Research paper – Averne – 2016 – Modelling concentrations of antimicrobial drugs_ comparative pharmacokinetics of cephalosporin antimicrobials and accuracy of allometric scalin