26 Potential dietary feed additives with antibacterial effects and their impact on performance of weaned piglets: A meta-analysis (Research paper, Vanrolleghem et al., 2019)

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Significant Impact Group(s): Feed / gut health \ Feed additives and supplements – Feed additives and supplements ; Specific alternatives

Species targeted: Pigs;
Age: Young;
Outcome Parameter(s): growth parameters; ‘average daily gain’ (ADG); ‘feed conversion ratio’ (FCR)
Summary: Between January 2010 and January 2017, 23 in vivo studies (comprising 50 trials) were published that evaluated the use of potential dietary feed additives (pDFA) against a positive control diet with antibiotics in weaned piglets, and reporting the performance parameters average daily gain’ (ADG) and ‘feed conversion ratio’ (FCR). The results of the meta-analysis clearly show that adding a pDFA at weaning can improve performance indicators compared to an untreated group (negative control), suggesting that pDFA could increase growth and improve feed conversion. As such, pDFA could potentially enhance production without the negative side effect of AMUs. Compared to the use of AMUs (positive control), the results of the meta-analysis show no overall significant difference. This is a beneficial result, as it suggests that the use of AMUs around weaning, a very commonly used practice, could be replaced by pDFA without significant negative effects on the performance indicators.
26 Research paper – Vanrolleghem – 2019 – Potential dietary feed additives with antibacterial effects and their impact on performance of weaned piglets: A meta-analysis. Vanrolleghem, W., Tanghe, S., Verstringe, S., Bruggeman, G., Papadopoulos, D., Trevisi, P., Zentek, J., Sarrazin, S. and J. Dewulf 2019 The Veterinary Journal 249: 24-32
Where to find the original material:
https://www.sciencedirect.com/science/article/pii/S1090023319300528; https://doi.org/10.1016/j.tvjl.2019.04.017
Country: BE, IT, DE

26 Research paper – Vanrolleghem – 2019 – Potential dietary feed additives with antibacterial effects and their impact on performance of

8 Antimicrobial usage in pig production check improve and reduce in Belgium and the EU (Research paper Postma 2016)

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8 Research paper
Antimicrobial usage in pig production : check, improve and reduce in Belgium and the EU (A DISSERTATION) by Postma, M. 2016 Antimicrobial usage in pig production : check, improve and reduce in Belgium and the EU : 306p.
Significant Impact Group(s): Biosecurity ; Prudent use AB
Species targeted: Pigs;
Age: Young; Adult;
Outcome Parameter(s): Reduced AMU; reduced costs on medicines; improved animal health and increased production
Summary: High antimicrobial usage (AMU) and the threat of antimicrobial resistance (AMR) highlighted the need for reduced AMU in pig production. Prevention of disease is necessary to obtain a reduced need for AM treatment. This study aimed at assessing possible associations between the biosecurity level, AMU and farm and production characteristics in order to advise on best practices for achieveing low AMU and maximum animal health and production. The research involved 227 farrow-to-finish pig herds in Belgium, France, Germany and Sweden in 2012/2013. 1) Establish a consensus defined daily dose animal (DDDA) for each active substance (AS) and administration route for porcine veterinary antimicrobial (AM) products authorized in four European countries, thus allowing cross-country quantification and comparison of antimicrobial usage (AMU) data. All veterinary AM products authorized for porcine use in Belgium, France, Germany and Sweden were listed for each administration route. First, separate DDDAs for each product were defined based on the recommended dosing for the main indication. Second, a consensus DDDA was established by taking the mean of the DDDAs for each product within a certain category of AS plus administration route. Large variations were observed for dosage and treatment duration recommendations between products and between countries for the same ASs. Only 6.8% of feed/water and 29.4% of parenteral AS groups had the same recommended dosage in the four countries. Four major recommendations have been formulated: (i) urgent need for harmonization of authorization and recommended summary of product characteristics (SPC) dosages; (ii) expand the developed preliminary DDDA list to include all authorized veterinary medicinal products in all EU member states and for all (food-producing) animal species; (iii) improved accessibility of country-specific SPC data would be preferable; and (iv) statement of the ‘long-acting’ duration of a product in the SP. 2) Nineteen alternatives to antimicrobial (AM) agents were ranked on perceived effectiveness, feasibility and return on investment (ROI) by 111 pig health experts from Belgium, Denmark, France, Germany, Sweden and Switzerland. Analysis showed that veterinary practitioners rank internal biosecurity, vaccination, use of zinc/metals, feed quality optimization and climate/environmental on average highest, while researchers and professors focused more on increased use of diagnostics and action plans. Financial incentives/penalties ranked low in all countries. Belgian respondents ranked feed quality significantly lower compared to the German respondents while reduction of stocking density was ranked higher in Belgium compared to Denmark. Further analysis showed veterinary practitioners
had a preference for more practical, common and already known alternatives. The results showed that improvements in biosecurity, increased use of vaccination, use of zinc/metals, feed quality improvement and regular diagnostic testing combined with a clear action plan were perceived to be the most promising alternatives to AMs in industrial pig production based on combined effectiveness, feasibility and ROI. 3) This study aimed at assessing the levels of implementation of biosecurity measures in pig production in four European Union (EU) countries . A cross-sectional study was conducted in 232 farrow-to-finish pig herds in Belgium, France, Germany and Sweden between 2012-2013. The biosecurity status in each
of these herds was described and quantified by using the risk-based scoring tool Biocheck.UGent (www.biocheck.ugent.be). Production and management characteristics, obtained from the herd management system and by interviewing the farmer, were analysed for their association with the biosecurity level. The results showed that there was substantial room
for improvement in the biosecurity status on many pig farms. Significant differences (p<0.01) both in internal and external biosecurity levels were observed between countries. The external biosecurity status, combining all measures taken to prevent disease introduction into the herd, was highest in Germany and lowest in France. The number of pathogens vaccinated against was significantly associated with internal biosecurity status, suggesting an overall more preventive approach towards the risk of disease transmission. A
higher external biosecurity was associated with more weaned piglets per sow per year.

8 Research paper – Postma – 2016 – Antimicrobial usage in pig production_check, improve and reduce in Belgium and the EU

Where to find the original material:
https://biblio.ugent.be/publication/7222359;
Country: BE

 

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Check improve and reduce. Prevention of disease is necessary to obtain a reduced need for AM treatment. This study aimed at assessing possible associations between the biosecurity level, AMU and farm and production characteristics in order to advise on best practices for achieveing low AMU and maximum animal health and production.

7 Reducing Antimicrobial Usage in Pig Production without Jeopardizing Production Parameters (Research paper, Postma et al., 2017)

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7 Research paper
Reducing Antimicrobial Usage in Pig Production without Jeopardizing Production Parameters by Postma, M., Vanderhaeghen, W., Sarrazin, S., Maes, D., and J. Dewulf 2017 Zoonoses and public health 64: 63-74
Significant Impact Group(s): Biosecurity ; Prudent use AB

Species targeted: Pigs;
Age: Young; Adult;
Outcome Parameter(s): Decreased AMU; Improved animal health so less disease and increased production; reduced costs on medicines so economical savings
Summary: This study evaluated the extent to which antimicrobial use (AMU) could be reduced in pig production by focusing on herd health, disease prevention and AMU. Their research involved 61 Flemish pig herds and included three visits per herd. During the visits, information was gathered on herd management, biosecurity status using the Biocheck.UGentTM tool, vaccinations, anthelmintic therapy and AMU. This info was then translated into a herd‐specific action plan which was discussed with the farmer and veterinarian/advisor during the visits. Significant improvements in biosecurity combined with additional vaccination, anthelmintic therapy and responsible AMU was seen. There was a 52% reduction in AMU in pigs from birth – slaughter. Increased biosecurity and decreased AMU were combined with increased numbers of weaned piglets per sow per year (+1.1), daily weight gain (+5.9 g/day) and mortality in the finisher period (−0.6%). Guided interventions as a team effort between farmer, veterinarians/advisors has shown to be a promising method in the reduction of AMU in pig production. Antimicrobial usage (AMU) has been described to be high in pig production. Although farmers are aware of the high usage, little is known about intervention to improve the situation. This study evaluated the extent to which AMU could be reduced in pig production by the optimization of herd management, biosecurity status, vaccination strategy, anthelmintic therapy and advice on prudent AMU. Furthermore, the effects of these interventions on the herd production results were explored. This intervention study was conducted on 61 Flemish pig herds and included three visits per herd. During the initial visit, information was gathered on herd management, biosecurity status (quantified by means of the Biocheck.UGentTM risk‐based scoring system), vaccination strategy, anthelmintic therapy and AMU. This info was then translated into a herd‐specific action plan which was discussed with the farmer and herd veterinarian/other advisors during the second visit. In the final herd visit (±8 months later), comparable data were obtained to evaluate the progress. Overall, a significant improvement of 2.4 points external and 7 points internal biosecurity on the herds was obtained, combined with additional vaccination, anthelmintic therapy and prudent AMU. This was accompanied by a significant reduction in the AMU with a decrease of 52% for the pigs from birth till slaughter and 32% for breeding animals, based on treatment incidences (TIs) and included an important reduction in the use of critically important antimicrobials. More importantly, the increased biosecurity levels and decreased AMU were combined with significantly improved technical results such as the number of weaned piglets per sow per year
(+1.1), daily weight gain (+5.9 g/day) and mortality in the finisher period (−0.6%). Guided interventions as a team effort of farmer and herd veterinarian/other advisors have shown to be a promising method in the reduction of AMU in pig production.
7 Research paper – Postma – 2017 – Reducing Antimicrobial Usage in Pig Production without Jeopardizing Production Parameters Where to find the original material:
https://onlinelibrary.wiley.com/doi/full/10.1111/zph.12283; https://doi.org/10.1111/zph.12283
Country: BE

 

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If combined, biosecurity principles, vaccination strategy, antihelmintic treatment and antimicrobial usage, along with a well-trained field team, the antimicrobial usage in general could be reduce and still obtain the set-out production parameters.