57 Evaluation of the use of dry cow antibiotics in low somatic cell count cows (Research paper; Scherpenzeel, 2014)

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Significant Impact Group(s): Prudent use AB \ Farmer
Species targeted: Dairy;
Age: Adult;
Outcome Parameter(s): Reduced AMU; Clinical mastitis; SCC; Bacteriological status
Summary: This study evaluated selective Dry Cow Therapy (DCT) in cows with low somatic cell count (SCC) at the last milk recording before drying off in various Dutch dairy herds. The incidence rate of Clinical Mastitis (CM) was found to be 1.7 times higher in quarters dried off without antibiotics as compared with quarters dried off with antibiotics. S.uberis was the main bug causing CM in both udders with and without DCT. SCC at calving and 14 d in milk was significantly higher in quarters dried off without antibiotics compared with quarters dried off with antibiotics. Selective DCT significantly increased the incidence of CM and SCC. The decrease in ABU by drying off quarters without DCT was not compensated by an increase in ABU for treating CM. Total ABU related to mastitis was reduced by 85% in these quarters.
57 Research paper – Scherpenzeel – 2014 – Evaluation of the use of dry cow antibiotics in low somatic cell count cows
Where to find the original material:
https://www.sciencedirect.com/science/article/pii/S0022030214002951; https://doi.org/10.3168/jds.2013-7655
Country: NL

57 Research paper – Scherpenzeel – 2014 – Evaluation of the use of dry cow antibiotics in low somatic cell count cows

56 Guidelines for prudent use of antimicrobials and their implications on antibiotic usage in veterinary medicine (Research paper; Ungemach, 2006)

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Significant Impact Group(s): Prudent use AB \ Veterinarian
Species targeted: Pigs; Poultry; Dairy; Beef; Sheep;
Age: Young; Adult;
Outcome Parameter(s): Reduced AMU
Summary: To reduce antimicrobial use (AMU) and minimize the development of resistance, compulsory guidelines for responsible use were published in Germany in 2000. Key elements of the guidelines are the use of antibiotics on the basis of an exact diagnosis, choosing a product with a narrow spectrum of activity, high safety margin and good tissue penetration, avoidance of critically important antibiotics, and adherence to the datasheet (no underdosing or prolonged dosing). Any deviations from the guidelines must be justified and recorded. Monitoring of AMU as medicated feed in pig production indicated a change in prescribing after guideline introduction. AMU declined from 4255 kg before the guidelines to 1145 kg by 2002, resulting in a reduction in the treatment days/animal from 31.6 to 13.6 days. The use of chlortetracycline decreased from 76% of the total antibiotics prescribed to 14.7% at the end of the study. These results suggest the responsible AMU guidelines have been an important tool to reduce AMU.
56 Research paper – Ungemach – 2006 – Guidelines for prudent use of antimicrobials and their implications on antibiotic usage in veterinary medicine
Where to find the original material:
https://www.sciencedirect.com/science/article/pii/S1438422106000634; https://doi.org/10.1016/j.ijmm.2006.01.059
Country: DE

56 Research paper – Ungemach – 2006 – Guidelines for prudent use of antimicrobials and their implications on antibiotic usage in veterinary medicine

55 Attitudes and perceptions of Dutch veterinarians on their role in the reduction of antimicrobial use in farm animals (Research paper; Speksnijder, 2015)

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Significant Impact Group(s): Prudent use AB \ Veterinarian
Species targeted: Pigs; Poultry; Dairy; Beef; Sheep;
Age: Young; Adult;
Outcome Parameter(s): Reduced AMU
Summary: A questionnaire to understand veterinary attitudes towards prescribing antibiotics found veterinarians working across species were comparable in their opinions towards the Dutch policy to halve veterinary antibiotic consumption. Less experienced veterinarians and those working with ruminants reported difficulty resisting farmers’ or colleagues’ demands for antibiotics compared with veterinarians working with pigs/poultry/veal. Contrastingly, more experience was associated with being less concerned about the contribution of veterinarians to antimicrobial resistance, considering it more important to keep the right to prescribe and sell antibiotics. The main perceived reasons for non-compliance with veterinary advice by farmers were related to finances and time, although pig/poultry/veal veterinarians highlighted conflicting advice from other advisors as a cause for non-compliance. This study suggests that less experienced veterinarians might require support to resist pressure from farmers/colleagues. Additionally, experienced veterinarians could be educated about overuse of antibiotics. Alternative approaches should be identified for veterinarians to preserve an income from advising and to prevent contradictory advice being a barrier.
55 Research paper – Speksnijder – 2015 – Attitudes and perceptions of Dutch veterinarians on their role in the reduction of antimicrobial use in farm animals
Where to find the original material:
https://www.sciencedirect.com/science/article/pii/S0167587715300039; https://doi.org/10.1016/j.prevetmed.2015.08.014
Country: NL

55 Research paper – Speksnijder – 2015 – Attitudes and perceptions of Dutch veterinarians on their role in the reduction of antimicrobial use in farm animals

Risk factors for ESBL-producing Escherichia coli on pig farms: A longitudinal study in the context of reduced use of antimicrobials (Research paper; Dohmen, 2017)

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Significant Impact Group(s): Prudent use AB \ Farmer ; Biosecurity
Species targeted: Pigs;
Age: Young; Adult;
Outcome Parameter(s): Presence of ESBL-E. coli; antimicrobial use; cephalosporin use at the farm
Summary: This study determined prevalence of ESBL-E. coli on pig farms and the effect of reducing veterinary antimicrobial use (AMU) and farm management practices on ESBL-E. coli occurrence on pig farms. During 2011 and 2013, 36 Dutch conventional pig farms participated in a longitudinal study (4 sampling times in 18 months). The number of farms with ESBL-E. coli carrying pigs decreased from 16 to 10 and the prevalence of ESBL-E. coli-positive pig samples halved from 27% to 13%.
The presence of ESBL-E. coli carrying pigs was not related to total AMU, but it was strongly determined by the presence or absence of cephalosporin use at the farm. Other farm management factors, related with improved biosecurity, were less frequently seen in ESBL-E. coli-positive farms (e.g. presence of a hygiene lock, pest control delivered by a professional). In conclusion, ESBL-E. coli prevalence decreased in pigs during 2011 and 2013 in the Netherlands.
54 Research paper – Dohmen – 2017 – Risk factors for ESBL-producing Escherichia coli on pig farms_A longitudinal study in the context of reduced use of antimicrobial
Where to find the original material:
http://dspace.library.uu.nl/bitstream/handle/1874/359723/journal.pone.0174094.pdf?sequence=1&isAllowed=y; https://doi.org/10.1371/journal.pone.0174094
Country: NL

54 Research paper – Dohmen – 2017 – Risk factors for ESBL-producing Escherichia coli on pig farms_A longitudinal study in the context of reduced use of antimicrobial

51 Effects of Reducing Antimicrobial Use and Applying a Cleaning and Disinfection Program in Veal Calf Farming: Experiences from an Intervention Study to Control Livestock-Associated MRSA (Research paper; Dorado-Garcia, 2015)

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Significant Impact Group(s): AMU reduction strategies ; Biosecurity
Species targeted: Dairy;
Age: Young;
Outcome Parameter(s): decrease in MRSA prevalence
Summary: A Dutch policy was set in place in 2010 promoting a reduction of antimicrobial use (AMU) in food-producing animals. In this context, a study evaluated 2 different strategies: a. with reducing of antimicrobials and b. with reduction of antimicrobials and with a cleaning and disinfection program. These results suggest that AMU reduction might be a good strategy for reducing MRSA in veal calf farming, however the effect of the cleaning and disinfection protocol used in this study was not effective. The study indicates that the long term AMU decrease is likely to lower MRSA levels in people living and/or working in veal farms.
51 Research paper – Dorado-García – 2015 – Effects of Reducing Antimicrobial Use and Applying a Cleaning and Disinfection Program in Veal Calf Farming
Where to find the original material:
https://journals.plos.org/plosone/article/file?type=printable&id=10.1371/journal.pone.0135826; https://doi.org/10.1371/journal.pone.0135826
Country: NL

51 Research paper – Dorado-García – 2015 – Effects of Reducing Antimicrobial Use and Applying a Cleaning and Disinfection Program in Veal Calf Fa

50 Determinants Associated with Veterinary Antimicrobial Prescribing in Farm Animals in the Netherlands: A Qualitative Study (Research paper; Speksnijder, 2014)

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Significant Impact Group(s): Prudent use AB \ Veterinarian
Species targeted: Pigs; Poultry; Dairy; Beef; Sheep;
Age: Young; Adult;
Outcome Parameter(s): Reduced AMU
Summary: Veterinarians are responsible for prescribing and overseeing antimicrobial use (AMU) in animals. An understanding of veterinarians’ prescribing practices can help to design interventions to reduce AMU in farming. This Dutch study identified factors that influence farm veterinarian prescribing. Research interviews with eleven farm veterinarians were conducted and analysed. There were many conflicting interests identified regarding antimicrobial prescribing by veterinarians. A veterinarian’s professional obligation to reduce animal suffering, financial dependency on clients, risk avoidance, concerns about own skills, lack of farmers’ compliance to veterinary recommendations, public health interests and personal beliefs regarding their contribution to AMR, were found to be factors in antimicrobial prescribing behaviour of farm veterinarians. Interventions to change prescribing behaviour could address veterinary attitudes, advisory skills and provide tools to deal with (perceived) pressure from farmers to prescribe antimicrobials. Policy measures could support farm veterinarians to shift to a more independent animal health consultant role.
50 Research paper – Speksnijder – 2014 – Determinants Associated with Veterinary Antimicrobial Prescribing in Farm Animals in the Netherlands_ A Qualitative Study
Where to find the original material:
https://onlinelibrary.wiley.com/doi/full/10.1111/zph.12168; https://doi.org/10.1111/zph.12168
Country: NL

50 Research paper – Speksnijder – 2014 – Determinants Associated with Veterinary Antimicrobial Prescribing in Farm Animals in the Netherlands_ A Qualitative Study

48 Economic optimization of selective dry cow treatment (Research paper; Scherpenzeel, 2018)

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Significant Impact Group(s): Pathogen management \ Managing sick animals \ Targeted use of antibiotics ; AMU reduction strategies
Species targeted: Dairy;
Age: Adult;
Outcome Parameter(s): Udder health status
Summary: The goal of this study was to identify a scenario with the lowest costs for mastitis associated with the dry period while restricting the percentage of cows that need to be dried off with dry cow antimicrobials. The costs of clinical/subclinical mastitis and the antimicrobial use were quantified. The economic impact of reducing the percentage of clinical mastitis was found to be much larger than reducing the bulk tank somatic cell count. The optimal percentage of cows to be dried off with antimicrobials depends on the udder health situation, expressed as the bulk tank somatic cell count and the occurrence of clinical mastitis. Selective dry cow treatment was economically more beneficial than blanket dry cow treatment, for all types of herds studied. Economic profits of selective dry cow treatment are greater if bulk tank somatic cell count and clinical mastitis incidence are lower.
48 Research paper – Scherpenzeel – 2018 – Economic optimization of selective dry cow treatment
Where to find the original material:
https://www.sciencedirect.com/science/article/pii/S0022030217311098; https://doi.org/10.3168/jds.2017-13076
Country: NL

48 Research paper – Scherpenzeel – 2018 – Economic optimization of selective dry cow treatment

44 Somatic cell count as a decision tool for selective dry cow therapy in Italy (Research paper; Zecconi, 2018)

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Significant Impact Group(s): AMU reduction strategies ; Pathogen management
Species targeted: Dairy;
Age: Adult;
Outcome Parameter(s): Udder health status
Summary: It is crucial to define a consistent and approved procedure to identify cows that need to be treated in a selective dry cow therapy approach. Somatic cell counts (SCC) from milk test records are a convenient, accurate and certified method. SCC values obtained before drying off or calculated as the average of lactation records can be used. The thresholds of 100,000 cells for primiparous cows and of 200,000 cells for pluriparous cows are suggested as an efficient and sustainable decision tool.
44 Research paper – Zecconi – 2018 – Somatic cell count as a decision tool for selective dry cow therapy in Italy
Where to find the original material:
https://www.tandfonline.com/doi/full/10.1080/1828051X.2018.1532328; https://doi.org/10.1080/1828051X.2018.1532328
Country: IT

44 Research paper – Zecconi – 2018 – Somatic cell count as a decision tool for selective dry cow therapy in Italy

41 Reduction of Veterinary Antimicrobial Use in the Netherlands. The Dutch Success Model (Research paper; Speksnijder, 2014)

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Significant Impact Group(s): AMU reduction strategies \ Legislation and incentives; Government ; Prudent use AB
Species targeted: Pigs; Poultry; Dairy; Beef; Sheep;
Outcome Parameter(s): Reduced AMU; Decrease in the use of antimicrobials [defined doses per animal year (DDD/Y)]
Summary: Veterinary overuse of antimicrobials contributes to the selection and spread of antimicrobial resistance which poses a public health risk. A series of events and discoveries of significant reservoirs of antimicrobial resistant pathogens in the Netherlands resulted in a successful collaboration between government and stakeholders to reduce antimicrobial use in farm animals. Total use of antimicrobials in farm animals in the Netherlands decreased with 56% in the period 2007–2012. A combination of compulsory and voluntary measures and reduction goals resulted in this decrease.
41 Research paper – Speksnijder – 2014 – Reduction of Veterinary Antimicrobial Use in the Netherlands_The Dutch Success Model
Where to find the original material:
https://onlinelibrary.wiley.com/doi/full/10.1111/zph.12167; https://doi.org/10.1111/zph.12167
Country: NL

41 Research paper – Speksnijder – 2014 – Reduction of Veterinary Antimicrobial Use in the Netherlands_The Dutch Success Model

40 Control of bovine mastitis in the 21st century: immunize or tolerize? (Research paper; Amadori, 2018)

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Significant Impact Group(s): Breeding for disease resistance or robustness ; Pathogen management
Species targeted: Dairy;
Age: Adult;
Outcome Parameter(s): Immune response in dairy cattle
Summary: Dairy cows face very high metabolic demands have increased difficulties adapting to the environment. This leads to increased replacement rates and frequent occurrence of diseases and drug use. This article reviews how a good understanding of the immune system is crucial in managing mastitis in dairy cows.
40 Research paper – Amadori – 2018 – Control of bovine mastitis in the 21st century_ immunize or tolerize
Where to find the original material:
http://nmconline.omnibooksonline.com/70526-nmc-1.4566730/t001-1.4567240/f001-1.4567241/a001-1.4567614?qr=1;
Country: IT

40 Research paper – Amadori – 2018 – Control of bovine mastitis in the 21st century_ immunize or tolerize