340 – Efficacy of non-antibiotic treatment options for digital dermatitis on an organic dairy farm (Research paper – Paudyal – 2020)

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340 Research paper – Paudyal – 2020 – Efficacy of non-antibiotic treatment options for digital dermatitis on an organic dairy farm

In Significant Impact Groups: Specific alternatives \ Other
Species targeted: Dairy;
Age: Adult;
Summary:
The objective of this study was to evaluate the efficacy of two non-antibiotic treatment options for digital dermatitis (DD) (1) topical application of copper sulfate and iodine (CUI); (2) topical application of honey and iodine (HOI); and (3) control subject to no treatment (CON). A randomized clinical trial was conducted using 70 multiparous Holstein cows with an early DD lesion at a USDA certified organic dairy farm in Northern Colorado, USA. The two non-antibiotic formulations resulted in an earlier transition to mature lesions compared with the control group. The CUI combination was the most effective treatment in reducing lesion size, pain, and lameness in affected cows. However, this combination had short-term efficacy, which did not persist throughout the duration of the study. The HOI combination produced only transient reduction in lesion size.

Where to find the original material: http://www.sciencedirect.com/science/article/pii/S1090023319301509; https://doi.org/10.1016/j.tvjl.2019.105417
Country: USA

326 – Vaccines as alternatives to antibiotics for food producing animals Part 2 (Research paper – Hoelzer – 2018)

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326 Research paper – Hoelzer – 2018 – Vaccines as alternatives to antibiotics for food producing animals Part 2

In Significant Impact Groups: Pathogen management \ Vaccination; Specific alternatives
Species targeted: Pigs; Poultry; Dairy; Beef; Sheep; Other;
Age: Young; Adult;
Summary:
This article highlights new approaches and potential solutions for the development of vaccines as alternatives to antibiotics in food producing animals. Many current vaccines fall short of ideal vaccines in one or more respects. Promising breakthroughs to overcome these limitations include new biotechnology techniques, new oral vaccine approaches, novel adjuvants, new delivery strategies based on bacterial spores, and live recombinant vectors; they also include new vaccination strategies in-ovo, and strategies that simultaneously protect against multiple pathogens. However, translating this research into commercial vaccines that effectively reduce the need for antibiotics will require close collaboration among stakeholders, for instance through public–private partnerships. Targeted research and development investments and concerted efforts by all affected are needed to realize the potential of vaccines to improve animal health, safeguard agricultural productivity, and reduce antibiotic consumption and resulting resistance risks.

Where to find the original material: https://veterinaryresearch.biomedcentral.com/articles/10.1186/s13567-018-0561-7?optIn=true; https://doi.org/10.1186/s13567-018-0561-7
Country: USA; UK; FR; BE; DE

325- Vaccines as alternatives to antibiotics for food producing animals Part 1 (Research paper – Hoelzer – 2018)

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325 Research paper – Hoelzer – 2018 – Vaccines as alternatives to antibiotics for food producing animals Part 1

In Significant Impact Groups: Pathogen management \ Vaccination; Specific alternatives
Species targeted: Pigs; Poultry; Dairy; Beef; Sheep;
Age: Young; Adult;
Summary:
Vaccines and other alternative products can help minimize the need for antibiotics by preventing and controlling infectious diseases in animal populations, and are central to the future success of animal agriculture. This article, synthesizes and expands on the expert panel discussions regarding opportunities, challenges and needs for the development of vaccines that may reduce the need for use of antibiotics in animals. Vaccines are widely used to prevent infections in food animals. Various studies have demonstrated that their animal agricultural use can lead to significant reductions in antibiotic consumption, making them promising alternatives to antibiotics. To be widely used in food producing animals, vaccines have to be safe, effective, easy to use, and cost-effective. Although vaccines have the potential to improve animal health, safeguard agricultural productivity, and reduce antibiotic consumption and resulting resistance risks, targeted research and development investments and concerted efforts are needed to realize that potential.

Where to find the original material: https://link.springer.com/article/10.1186/s13567-018-0560-8; https://doi.org/10.1186/s13567-018-0560-8
Country: USA; UK; FR; BE; DE

324- Use of phytobiotics in broiler nutrition an alternative to infeed antibiotics (Research paper – Grashorn – 2010)

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324 Research paper – Grashorn – 2010 – Use of phytobiotics in broiler nutrition an alternative to infeed antibiotics

In Significant Impact Groups: Feed / gut health \ Feed additives and supplements; Specific alternatives
Species targeted: Poultry;
Age: Young; Adult;
Summary:
After the ban of antibiotic growth promoters (AGP) in the EU many alternative substances have been investigated for their potential to replace AGPs. Phytobiotics are discussed as one promising alternative due because they contain many pharmacologically active compounds. A huge number of studies have confirmed a wide range of activities of phytobiotics in poultry nutrition like stimulation of feed intake, antimicrobial, coccidiostatic and anthelmintic effects. The present paper gives a short review on the characteristics of phytobiotics, on the potential mode of action and on the effects of phytobiotics in diets on performance, carcass and meat quality and health status in broilers. Furthermore, it addresses possible safety concerns involving application of phytobiotics.
324

Where to find the original material: http://www.jafs.com.pl/Use-of-phytobiotics-in-broiler-nutrition-n-an-alternative-to-infeed-antibiotics-,66297,0,2.html; https://doi.org/10.22358/jafs/66297/2010
Country: DE

300 – The combined use of ozone therapy and autologous platelet-rich plasma as an alternative approach to foot rot treatment for sheep – A preliminary study (Research paper – Szpondera – 2017)

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300 Research paper – Szpondera – 2017 – The combined use of ozone therapy and autologous platelet-rich plasma as an alternative approach to foot rot treatment for sheep_ A preliminary study

In Significant Impact Groups: Pathogen management \ Eradication; Specific alternatives
Species targeted: Sheep;
Age: Not stated;
Summary:
This study aimed to evaluate the effectiveness of ozone therapy and platelet rich plasma (PRP) in the treatment of acute foot rot. 10 sheep suffering from foot rot were treated and compared to a control group of 5 healthy sheep. Treatment consisted of local ozone application and then with non-healing cases, the application of PRP. We analysed effectiveness of combined treatment and the potential toxicity of ozone therapy. Complete recovery was achieved after local ozone treatment in 6/10 sheep. The remaining four animals also healed after the subsequent PRP therapy. Our results showed that ozone treatment did not cause major blood or inflammatory changes. We demonstrated that the local application of ozone and PRP proved to be an effective foot rot treatment that avoids the use of antibiotics/ disinfectants. However, due to the relatively high costs and time requirements, it is potentially most suitable for smaller farms.

Where to find the original material: https://www.sciencedirect.com/science/article/abs/pii/S0921448817302201?via%3Dihub; https://doi.org/10.1016/j.smallrumres.2017.08.015
Country: PO

294 – Oral administration of synthetic porcine beta-defensin-2 improves growth performance and cecal microbial flora and down-regulates the expression of intestinal toll-like receptor-4 and inflammatory cytokines in weaned piglets challenged with enterotoxigenic Escherichia coli (Research paper – Tang – 2016)

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294 Research paper – Tang – 2016 – Oral administration of synthetic porcine beta-defensin-2 improves growth performance and cecal microbial flora and down-regulates the expression of intesti

In Significant Impact Groups: Feed / gut health \ Feed additives and supplements; Specific alternatives
Species targeted: Pigs;
Age: Young;
Summary:
Synthetic porcine beta-defensin-2 (pBD-2) was tested as an alternative to antimicrobial growth-promoters in pig production. Thirty 21-day weaned piglets were challenged with Escherichia coli, and orally dosed with either sterile water (CON), pBD-2 (BD) or neomycin sulphate (NS) twice daily for 21 days. Therefore, pBD-2 has antimicrobial activity in piglets, and it can improve growth performance, reduce inflammatory cytokine expression and affect intestinal morphological indices in the same way as probiotics. Moreover, pBD-2 has a more positive effect on intestinal morphological indices and intestinal probiotics of piglets than does NS. Therefore, the present results suggest that pBD-2 may be a suitable replacement for NS in piglets.

Where to find the original material: https://onlinelibrary.wiley.com/doi/full/10.1111/asj.12540; https://doi.org/10.1111/asj.12540
Country: CN

293 – Effects of dietary hop beta-acids or colistin on the performance nutrient digestibility and intestinal health of weanling pigs (Research paper – Sbardella – 2016)

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293 Research paper – Sbardella – 2016 – Effects of dietary hop beta-acids or colistin on the performance nutrient digestibility and intestinal health of weanling pigs

In Significant Impact Groups: Feed / gut health \ Feed additives and supplements; Specific alternatives
Species targeted: Pigs;
Age: Young;
Summary:
This study evaluated the effects of hop (Humulus lupulus) beta-acids or colistin on several parameters, namely body weight (BW), Average feed intake (ADFI) Average daily gain (ADG), gain:feed ratio (G:F). Two hundred 21-d weaned pigs fed diets supplemented with 0 (negative control), 120, 240, or 360 mg/kg hop beta-acids, or with 40 mg/kg colistin (antimicrobial control) during a 35-d experiment. Increasing dietary levels of hop beta-acids improved linearly BW, ADG, G:F,and digestibility in weanling pigs. The colistin treatment improved BW, ADG, and G:F compared to the negative control. No difference in growth performance was observed between hop beta-acids levels and colistin. Overall, the occurrence of diarrhea was lower for colistin, negative control, and 360 mg/kg hop beta-acids than for other levels. In conclusion, dietary hop beta-acids concentrations up to 360 mg/kg improved weanling pig growth rate by affecting the efficiency of feed utilization, as well as observed for colistin.

Where to find the original material: https://www.sciencedirect.com/science/article/pii/S0377840116301420; http://dx.doi.org/10.1016/j.anifeedsci.2016.04.007
Country: BR

287 – Use of a micro-encapsulated eucalyptus-medium chain fatty acids product as an alternative to zinc oxide and antibiotics (Research paper – Han – 2011)

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287 Research paper – Han – 2011 – Use of a micro-encapsulated eucalyptus-medium chain fatty acids product as an alternative to zinc oxide and antibiotics

In Significant Impact Groups: Specific alternatives \ New antibiotics; Feed / gut health
Species targeted: Pigs;
Age: Young;
Summary:
The effects of eucalyptus-medium chain fatty acids (E-MCFAs), zinc oxide (ZnO), and antibiotics on performance, nutrient digestibility, and serum chemistry parameters of were studied in nursery pigs. Three experiments were conducted. Recently weaned pigs, were given five treatments consisting of a basal diet or the basal diet supplemented with antibiotics (33 mg per kg tiamulin and 44 mg per kg lincomycin), ZnO (1500 or 2500 mg per kg), or 0.1% E-MCFAs (Experiments One and Two). In Experiment Three, 1% diatomaceous earth was added and the negative control was not used. In all three experiments, performance of pigs fed the four supplemented diets did not differ. Digestibility was higher in the diet supplemented with E-MCFAs than in diets supplemented with ZnO or antibiotics. This study indicates eucalyptus-MCFAs can be successfully used as a growth promoter in diets fed to nursery pigs.

Where to find the original material: https://www.aasv.org/shap/issues/v19n1/v19n1p34.html;
Country: KR, CA

285 – Effect of Brazilian red pepper (Schinus terebinthifolius Raddi) essential oil on performance diarrhea and gut health of weanling pigs (Research paper – Gois – 2016)

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285 Research paper – Gois – 2016 – Effect of Brazilian red pepper (Schinus terebinthifolius Raddi) essential oil on performance diarrhea and gut health of weanling pigs

In Significant Impact Groups: Feed / gut health \ Feed additives and supplements; Specific alternatives
Species targeted: Pigs;
Age: Young;
Summary:
This study aimed to evaluate the effects of dietary Brazilian red pepper essential oil and an antimicrobial agent on weanling pig growth performance, diarrhea, pH of the digestive content, small intestine cells, and intestine microbial counts. Ninety weanling castrated male pigs were given five treatments: a diet supplemented with 0 (negative control), 500, 1000, and 1500mg/kg Brazilian red pepper essential oil vs with 120mg/kg chlorohydroxyquinoline (antibiotic). Treatments had no effect on growth performance, diarrhea occurrence, pH of the digestive content, gut mucosa and intestinal microbial counts of weanling pigs. However, pigs fed the diet containing 500mg/kg essential oil had thicker gut mucosa than those fed diets containing the antibiotic or 1000 and 1500 mg/ kg essential oil. Thus, Brazilian red pepper essential oil and the antibiotic are of limited benefit for enhancing the growth of weanling pigs. Nonetheless, the effectiveness of growth enhancer additives may be reduced in non-challenging situations.

Where to find the original material: https://www.sciencedirect.com/science/article/pii/S1871141315300354; https://doi.org/10.1016/j.livsci.2015.11.009
Country: BR

284 – Essential oils and aromatic plants in animal feeding – A European perspective – A review (Research paper – Franz – 2009)

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284 Research paper – Franz – 2009 – Essential oils and aromatic plants in animal feeding – a European perspective A review

In Significant Impact Groups: Specific alternatives \ Pre-/probiotics
Species targeted: Pigs; Poultry; Dairy; Beef; Sheep; Other;
Age: Young; Adult;
Summary:
In the last years there has been substantial interest on the use of aromatic herbs and essential oils as feed additives in animal nutrition. Significant antimicrobial effects of several essential oils and compounds against gut organisms in farm animals have been shown. Specific Escherichia coli strains could be controlled by in-feed application of carvacrol-rich essential oils, and the effect of some essential oil components against Clostridium perfringens and necrotic enteritis was confirmed in poultry. In ruminants, an improvement of the digestion was observed. Aromatic plants and essential oil compounds improve stability and palatability of animal feed and improved shelf-life and quality of animal products. The ‘growth-promoting effect’ of essential oils is not as evident. Nonetheless, the overall efficacy of essential oils and aromatic herbs, especially their impact on the health status and benefit of animals and humans (via the food chain) is encouraging further research and development in this field.

Where to find the original material: Essential oils and aromatic plants in animal feeding – a European perspective. A review. – Franz – 2010 – Flavour and Fragrance Journal – Wiley Online Library; https://doi.org/10.1002/ffj.1967
Country: TR; AT