387 – From farm management to bacteriophage therapy strategies to reduce antibiotic use (Research paper – Kahn – 2019)

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387 Research paper – Kahn – 2019 – From farm management to bacteriophage therapy strategies to reduce antibiotic use

Specific alternatives \ Immunomodulators

Species targeted: Pigs; Poultry; Dairy; Beef; Sheep;
Age: Different for different species;
Summary:
A number of effective or commercially viable alternatives have been implemented to reduce the use of antibiotics in livestock. The most well-established strategies are flock and herd management practices to mitigate disease introduction and spread, and, subsequently, reduce the need for antibiotic use. While vaccines in food animal production have been used to prevent both bacterial and viral diseases, but historically, most vaccines have targeted viral diseases. Though vaccines against viral diseases can help reduce the need for antibiotic use by controlling the spread of secondary bacterial infections, more recent vaccines under development specifically target bacteria. New developments in selecting and potentially tailoring bacteriophages provide a promising avenue for controlling pathogenic bacteria without the need for traditional small-molecule antibiotics. In this article we discuss these established and emerging strategies, which are anticipated to reduce the reliance on antibiotics in food animal production and should reduce the prevalence and transmission to humans of antimicrobial resistant bacteria from these systems.

Where to find the original material: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850639/; 10.1111/nyas.14034

Country: Canada, New York

375- Essential oils and aromatic plants in animal feeding – A European perspective A review (Research paper – Franz – 2010)

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375 Research paper – Franz – 2010 – Essential oils and aromatic plants in animal feeding – a European perspective A review

In Significant Impact Groups: Prudent use AB \ Farmer
Species targeted: Pigs; Poultry; Dairy;
Age: Not stated;
Summary:
This article gives an overview of application of plant and herb extracts as substitute for antibiotics in livestock production. The authors are experts in the field of European as well as non-European herbs, plant extracts and aromatic plant substances, and contributed to the classification and standardisation of these substances. Depending on the intended applications, a portfolio of blends is possible. The article also shows the clear potential of traditional Chinese medicinal plants in improving livestock performance and health. Not all plant extracts are already accepted in European legislation, but leaves room for innovative solutions.

Where to find the original material: https://onlinelibrary.wiley.com/doi/abs/10.1002/ffj.1967; https://doi.org/10.1002/ffj.1967
Country: AT

374- Antibiotic alternatives_ the substitution of antibiotics in animal husbandry (Research paper – Chengn – 2014)

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374 Research paper – Chengn – 2014 – Antibiotic alternatives_ the substitution of antibiotics in animal husbandry

In Significant Impact Groups: Prudent use AB \ Farmer
Species targeted: Pigs; Poultry; Dairy; Beef; Sheep;
Age: Different for different species;
Summary:
This article provides an overview of substitutes for antibiotics, having potential in livestock production. The article describes a range of antibiotic alternatives, ranging from plant extract to prebiotic functional feed ingredients. All of the functional feed ingredients show potential in improving animal performance, as well as a contribution to increase health in terrestrial livestock. There is no clear preference for a particular functional feed ingredient, and final selection will mainly depend on farmer expectations as well as commercial price setting (which is not a fixed asset).

Where to find the original material: https://www.frontiersin.org/articles/10.3389/fmicb.2014.00217/full; doi: 10.3389/fmicb.2014.00217
Country: CN

373 International instruments on the use of antimicrobials across the human animal and plant sectors by WHO FAO OIE (Tools & Checklists)

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373 ToolsChecklists – International instruments on the use of antimicrobials across the human animal and plant sectors by WHO FAO OIE

In Significant Impact Groups: Prudent use AB
Species targeted: Pigs; Poultry; Dairy; Beef; Sheep;
Summary:
Instruments that contain standards for governments or other actors are included. These include international guidelines that have been adopted by public entities through formal processes if they provide standards (understood as clear instructions/ guidance on the use of antimicrobials).
The compilation excludes resolutions, declarations, (action) plans or other documents that only state intentions or objectives and that do not contain implementable standards. International standards adopted by private entities and business associations are also excluded.

Where to find the original material: https://apps.who.int/iris/rest/bitstreams/1314292/retrieve;
Country: Germany;

372 – Antimicrobial Usage and Resistance in Dairy Cattle Production (Research paper – Loo – 2019)

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372 Research paper – Loo – 2019 – Antimicrobial Usage and Resistance in Dairy Cattle Production

In Significant Impact Groups: Prudent use AB \ None
Species targeted: Dairy;
Age: Not stated;
Summary:
The chapter explain antimicrobial usage in dairy cattle production and the recent approaches and challenges on AMR.

Where to find the original material: https://www.intechopen.com/books/veterinary-medicine-and-pharmaceuticals/antimicrobial-usage-and-resistance-in-dairy-cattle-production; https://doi.org/10.5772/intechopen.81365
Country: MY

371- Practical strategies to reduce antimicrobial use in dairy farming (Research report – EuroDairy – 2018)

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371 Research report – EuroDairy – 2018 – Practical strategies to reduce antimicrobial use in dairy farming

In Significant Impact Groups: AMU reduction strategies \ None
Species targeted: Dairy;
Age: Adult; Young;
Summary:
This report highlights the extent of quantitative reduction which can be achieved, both in overall antimicrobial use, and especially of Critically Important Antibiotics (CIA’s) whose efficacy must be preserved for use in human medicine. EuroDairy gathered intelligence through its partners and wider networks, organized a cross border workshop, farmer exchange visits, technical webinars, and linked to regional Operational Groups focussed on reducing antibiotics. The only way to sustainably reduce the risk of Antimicrobial Resistance (AMR) is through an integrated approach to disease control, which sustainably improves animal health. Hotspots for antibiotic use are treatment for mastitis (including dry cow therapy), lameness and foot health, respiratory disease and young stock health.

Where to find the original material: https://ec.europa.eu/research/participants/documents/downloadPublic?documentIds=080166e5c0d054f7&appId=PPGMS;
Country: SE; DK; NL; UK; BE; FR; ES

370 – Antimicrobial Effect of Zophobas morio Hemolymph against Bovine Mastitis Pathogens (Research paper – Du – 2020)

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370 Research paper – Du – 2020 – Antimicrobial Effect of Zophobas morio Hemolymph against Bovine Mastitis Pathogens

In Significant Impact Groups: Specific alternatives
Species targeted: Dairy;
Age: Adult;
Summary:
In the present study, we showed the protective effect of Zophobas morio (Z. morio) hemolymph on bovine mammary epithelial cells against bacterial infection. Z. morio hemolymph directly kills both Gram-positive and Gram-negative bacteria through membrane permeation and prevents the adhesion of E. coli or the clinically isolated S. simulans strain to bovine mammary epithelial (MAC-T) cells. In addition, Z. morio hemolymph downregulates the expression of nucleotide-binding oligomerization domain (NOD)-like receptor family member pyrin domain-containing protein 3 (NLRP3), caspase-1, and NLRP6, as well as inhibits the secretion of interleukin-1 beta (IL-1 beta) and IL-18, which attenuates E. coli or S. simulans-induced pyroptosis. Overall, our results suggest the potential role of Z. morio hemolymph as a novel therapeutic candidate for bovine mastitis.

Where to find the original material: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601528/; https://doi.org/10.3390/microorganisms8101488
Country: CN

369 – Bovine mastitis_ risk factors therapeutic strategies and alternative treatments — A review (Research paper – Cheng – 2020)

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369 Research paper – Cheng – 2020 – Bovine mastitis_ risk factors therapeutic strategies and alternative treatments — A review

Specific alternatives \ Other
Species targeted: Dairy;
Age: Adult;
Summary:
The etiological agents of Bovine mastitis include a variety of gram-positive and gram-negative bacteria, and can be either contagious (e.g., Staphylococcus aureus, Streptococcus agalactiae, Mycoplasma spp.) or environmental (e.g., Escherichia coli, Enterococcus spp., coagulase-negative Staphylococcus, Streptococcus uberis). The extensive use of antibiotics increased concerns about emergence of antibiotic-resistant pathogens and that led the dairy industries to reduce the use of antibiotics. This review provides an overview of bovine mastitis in the aspects of risk factors, control and treatments, and emerging therapeutic alternatives in the control of bovine mastitis.

Where to find the original material:
Country: CN

358 – Perceptions and attitudes regarding antibiotic resistance in Germany – A cross-sectoral survey amongst physicians veterinarians farmers and the general (Research paper – Schneider – 2018)

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358 Research paper – Schneider – 2018 – Perceptions and attitudes regarding antibiotic resistance in Germany_a cross-sectoral survey amongst physicians veterinarians farmers and the general

In Significant Impact Groups: Prudent use AB \ Farmer
Species targeted: Pigs; Poultry; Dairy; Beef;
Age: Not stated;
Summary:
Perceptions and attitudes towards antibiotic resistance among general practitioners, hospital physicians, veterinarians, pig farmers and the general public were compared. Farmers were predominantly satisfied with existing solutions. Farmers had three times better basic knowledge of antibiotic resistance and knew twice as many people with multiple drug resistance organism problems than the general public. They also received information on antibiotic resistance more often from their veterinarians than patients did from their doctors. This study reveals considerable differences in perceptions and attitudes to antibiotic resistance among the groups investigated. Results promote mutual understanding and thus support the One Health approach.

Where to find the original material: https://pubmed.ncbi.nlm.nih.gov/29590400/; https://doi.org/10.1093/jac/dky100
Country: DE

357 – Comparison of three protocols of vaccination against Bovine Respiratory Disease in fattening commercial farms (Research paper – Mounaix – 2018)

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357 Research paper – Mounaix – 2018 – Comparison of three protocols of vaccination against Bovine Respiratory Disease in fattening commercial farms

In Significant Impact Groups: Pathogen management \ Vaccination
Species targeted: Beef;
Age: Young;
Summary:
Three protocols of vaccination against Bovine Respiratory Disease (BRD; Bovilis Bovigrip®) for young Charolais cattle were conducted in commercial feedlots to identify respective benefits. The average daily gain was significantly higher (p<0,05) when animals were completely vaccinated (2 shots) at breeding farms (early vaccination) compared to those where part of the vaccination was done at the assembly center (intermediate vaccination). The number of cattle which were observed as sick by farmers was low in average, as well as the proportion which were treated by them (<15%/lot) but no significant difference could be demonstrated between protocols. In the context of reducing medication inputs, this experiment suggests the benefits to vaccinate cattle at the breeding farm to prevent and decrease BRD incidence in feedlots.

Where to find the original material: http://www.journees3r.fr/IMG/pdf/texte_7_reduction_intrants_b-mounaix-2.pdf;
Country: FR